[학회발표] 2024년 추계 신경외과 학회

[학회 구연 발표]

발표자: 김모이네 교수님

일시: 2024.10.18 16:00

장소: 인터컨티넨탈 파르나스

발표 주제: Administration of calcium and magnesium in acute intracerebral hemorrhage patients: Assessing safety and feasibility in a pilot study 

Authors :

Seungjoo Lee 1, Wonhyoung Park 1, Jun Ha Hwang 1, Jae Hyun Kim 2, Yeongu Chung 3, Si Un Lee 5, Joonho Byun 4, Jung Cheol Park 1, Jae Sung Ahn 1

Affiliations :

Ulsan University Asan Medical Center1, Keimyung University Dongsan Medical Center2, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine3, Korea University Guro Hospital, Korea University College of Medicine, 4, Seoul National University Bundang Hospital5

Abstract Title :

SS(II2)-1 Administration of calcium and magnesium in acute intracerebral hemorrhage patients: Assessing safety and feasibility in a pilot study 

Purpose :

Serum calcium and magnesium levels are a key factor of the coagulation cascade and may potentially contribute to the pathophysiology of intracerebral hemorrhage (ICH) expansion. The aim of this study was to attain and sustain target levels of serum calcium and magnesium for three days following admission.

Methods :

A single-blind, prospective, multicenter randomized study was conducted from 2019 to 2022 years, enrolling acute ICH patients aged 18-80 years, with radiological diagnosis and without surgical intervention. Participants were randomly assigned in a 1:1 ratio to either the study group or the control group. In the study group, the target serum levels of calcium (9 – 10.2 mg/dl) and magnesium (2 – 3 mg/dl) were actively achieved and maintained for a duration of 3 days following admission. The primary outcome was the expansion of ICH volume within the first 3 days between the study group and the control groups. 

Result :

After implementing inclusion/exclusion criteria, 105 out of 354 patients remained in the study. There were no significant differences in ICH volume on hospital days 2 and 3 between the groups. Admission factors including Glasgow coma scale score, hemoglobin level, ICH volume, and spot sign showed significant correlations in multivariate analysis. On the third day of hospitalization, admission serum magnesium levels showed a significant correlation with ICH expansion, whereas calcium levels did not show a significant association.

Conclusion :

Admission serum magnesium correlates with the hematoma expansion in patients with acute ICH. Hence magnesium may be a promising therapeutic target for acute ICH treatment trials.