Intracranial Pressure Soon After Hemicraniectomy in Malignant Middle Cerebral Artery Infarction, J Intensive Care Med. 2018 [참여저자]

Sang-Beom Jeon 1, Jung Cheol Park 2, Sun U Kwon 1, Yeon-Jung Kim 1, Seungjoo Lee 2, Dong-Wha Kang 1, Jong S Kim 1

10.1177/0885066616675598

Abstract

Background: Decompressive hemicraniectomy reduces secondary brain injury related to brain edema and increased intracranial pressure (ICP) in patients with malignant middle cerebral artery infarction (MMI). However, a substantial proportion of patients still die despite hemicraniectomy due to refractory brain swelling.

Objective: We aim to investigate whether ICP measured immediately after hemicraniectomy may indicate decompression effects and predict survival in patients with MMI.

Methods: We included 25 patients with MMI who underwent ICP monitoring and brain computed tomography within the first hour of hemicraniectomy. Midline shifts were measured as radiological surrogates of decompression. The Glasgow Coma Scale and pupillary enlargements during the first day after hemicraniectomy were assessed as clinical surrogates of decompression. Long-term survival status at 6 months was used as the final outcome. We analyzed the relationships between early ICP and findings of midline shift, Glasgow Coma Scale, pupillary enlargement, and survival.

Results: Initial ICP was correlated with mean ICP ( P < .001) and maximal ICP ( P < .001) during the first postoperative day. Intracranial pressure was associated with midline shifts ( P = .009), lower Glasgow Coma Scale scores ( P = .025), and the pupillary enlargement ( P = .015). Sixteen (64.0%) patients survived at 6 months. In a Cox proportional hazard model, elevated ICP was associated with mortality at 6 months (hazard ratio: 1.13; 95% confidence interval: 1.03-1.24; P = .008).

Conclusion: Increase in ICP soon after hemicraniectomy was associated with midline shift, poor neurological status, and mortality in patients with MMI. Measurements of ICP soon after hemicraniectomy may permit earlier interventions as well as more refined clinical assessments.

Keywords: decompressive surgery; hemispheric infarction; intracranial pressure; middle cerebral artery occlusion.

Figure 3. Early intracranial pressure (ICP) and survival after hemicraniectomy. The proportions of surviving patients stratified by initial intracranial hypertension are shown in Kaplan-Meier curves. The curves differed significantly based on the log-rank test.